The work is devoted to the study of the effect of electrical pulses on the processes of cisplatin transport through the plasma membrane. Technical devices based on the application of this technology are used to increase cellular uptake of cytotoxic agents within certain cancer treatment strategies. This article presents the results of mathematical modeling performed using computer methods that allow us to study the influence of different pulse parameters (amplitude, duration, frequency) on the efficiency of cisplatin transport. Numerical experiments using various difference schemes and mathematical models that take into account the physical properties of the plasma membrane have been performed. The results obtained allow us to better understand the mechanisms of the impact of electrical impulses on the processes of cisplatin transport, which may be of practical importance for the development of new methods of drug delivery and cancer treatment.

Keywords: mathematical modeling, software package, electroporation, cisplastin transport, plasma membrane, computational experiment